Episode 15 of CardioPod: Heart of the Matter is Live!
Our latest podcast episode is live! ????
Who should have access to clinical trial data—and what does it mean for transparency, trust, and collaboration?
Host Christopher O’Connor, MD is joined by Robert Califf, MD; Michael Bristow, MD; Scott Solomon, MD; Marvin Konstam, MD; and Mona Fiuzat, PharmD for a timely discussion on the future of data sharing in clinical research.
Episode 15 of CardioPod: Heart of the Matter is Live!
Let Us Call It Cardiogenic Preshock: A Working Definition From the Heart Failure Collaboratory
This consensus from HFCollaboratory introduces the concept of cardiogenic preshock, a transitional state between acute decompensated heart failure (ADHF) and cardiogenic shock, aimed at addressing limitations of current classifications in capturing the continuum of hemodynamic deterioration. The framework, developed through multidisciplinary collaboration, defines actionable criteria to improve patient stratification. By characterizing distinct phenotypes—such as isolated low cardiac index and isolated hypotension—the proposal enhances early recognition and risk assessment, supporting precision-guided interventions.
Let Us Call It Cardiogenic Preshock: A Working Definition From the Heart Failure Collaboratory
Capturing Totality of Treatment Effects: A Model-Free Approach to Analyzing Multiple Event-Time Data From Heart Failure Studies
This article from the HFC members presents a new model-free analytical approach to evaluating treatment effects in heart failure trials. Traditional methods often focus only on the first event, by incorporating recurrent events and survival, this method provides a more comprehensive and clinically meaningful assesment of therapies. Specifically, it introduces a composite endpoint non-fatal event-free survival, that adjusts for between group differences in follow up time minimizing survival bias.
Capturing Totality of Treatment Effects: A Model-Free Approach to Analyzing Multiple Event-Time Data From Heart Failure Studies
JACC Article commending model partnership between FDA and HFC
"One model of particularly close engagement is the formation of public-private-partnerships such as the Heart Failure Collaboratory and the Heart Valve Collaboratory. Such collaboratories bridge the gap between clinical practice and regulatory science, advancing clinical research through close communication among clinicians, regulators, and industry regarding focused disease conditions."
JACC Article commending model partnership between FDA and HFC
ACC News Story: HFC Study Finds Increased Clinical Trial Diversity Could Help Close Gaps in Who Receives Newly Approved Treatments
American College of Cardiology News Story: Increasing diversity in clinical trial enrollment may impact who receives innovations, based on findings from a study conducted on behalf of the Heart Failure Collaboratory and being presented at ACC.24 in Atlanta, GA. A separate state-of-the-art review article, also being presented at ACC.24 and published in JACC: Heart Failure, addresses the urgent need to recruit and train new members of data monitoring committees.
ACC News Story: HFC Study Finds Increased Clinical Trial Diversity Could Help Close Gaps in Who Receives Newly Approved Treatments
Collaboration with the American Heart Association
The Heart Failure Collaboratory (HFC) announces new collaboration with the American Heart Association (AHA) for the annual HFC Site-Based Research Awards. The 2024 awards will be presented during an event at AHA’s Scientific Sessions in Chicago. Nominations are now open!